Cytarabine hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cytarabine hydrochloride是治疗白血细胞癌的有效药物[1].
Cytarabine hydrochloride是一种脱氧胞苷(dC)类似物.Cytarabine hydrochloride被磷酸化成三磷酸形式,从而与dCTP竞争掺入DNA.据报道,Cytarabine hydrochloride掺入到DNA中,抑制DNA和RNA聚合酶功能,最终阻断DNA合成.在急性骨髓性白血病(AML)细胞生长抑制实验中,Cytarabine hydrochloride掺入呈剂量依赖性地抑制细胞生长,对CCRF-CEM\CEM/AraC8C和CEM/dCK细胞系的IC50值分别为16 nM\103 μM和223 μM.WST-1试验表明,在逆转录病毒传感器大鼠白血病KA细胞中,Cytarabine hydrochloride对KA\KA/GFP和KA/wt的IC50值分别为0.69 μM\1.73 μM和0.037 μM[1,2].
参考文献：
[1] Tobias SC1, Borch RF. Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug. Mol Pharm. 2004 Mar-Apr; 1(2):112-6.
[2] Veuger MJ1, Heemskerk MH, Honders MW, Willemze R, Barge RM. Functional role of alternatively spliced deoxycytidine kinase in sensitivity to cytarabine of acute myeloid leukemic cells. Blood. 2002 Feb 15; 99(4):1373-80.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 279.68 |
| Cas No. | 69-74-9 |
| Formula | C9H14ClN3O5 |
| Solubility | insoluble in EtOH; ≥14.2 mg/mL in DMSO; ≥64.2 mg/mL in H2O |
| Chemical Name | 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
