Cyclopiazonic acid
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cyclopiazonic acid is a neurotoxic secondary metabolite produced by A. flavus and is a nanomolar inhibitor of endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA). Cyclobenzoic acid does not inhibit many other types of membrane-bound ATPase, it can effectively inhibit SERCA in intact tissues, smooth muscle and endothelium, and isolated cells[1,2]. It is an effective inducer of plant cell death[3].
References:
[1]. Mumtaz S, Burdyga G, Borisova L, et al. The mechanism of agonist induced Ca2+ signalling in intact endothelial cells studied confocally in in situ arteries. Cell Calcium, 2011, 49(1): 66-77.
[2]. Berra-Romani R, Raqeeb A, Torres-Jácome J, et al. The mechanism of injury-induced intracellular calcium concentration oscillations in the endothelium of excised rat aorta. Journal of Vascular Research, 2012, 49(1): 65-76.
[3]. Chalivendra S C, et al. Cyclopiazonic Acid Is a Pathogenicity Factor for Aspergillus flavus and a Promising Target for Screening Germplasm for Ear Rot Resistance. Mol Plant Microbe Interact, 2017, 30(5): 361-373.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 336.39 |
| Cas No. | 18172-33-3 |
| Formula | C20H20N2O3 |
| Solubility | Soluble in DMSO |
| Chemical Name | (6aS,11aR,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-6a,7,11a,11b-tetrahydro-2H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9(6H)-one |
| SDF | Download SDF |
| Canonical SMILES | OC1=C(C(C)=O)C(N2C(C)(C)[C@@H](CC3=C4C5=CNC4=CC=C3)[C@H]5[C@@H]21)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
