Cyclo (-RGDfK)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50：对细胞粘附显示出抑制作用，IC50范围为0.1至1 μM。
有一系列可识别并结合三肽序列RGD（精氨酸-甘氨酸-天冬氨酸）的整联蛋白亚型，代表参与细胞粘附最显著的识别基序。其中，cyclo (-RGDfK)已被广泛应用于生物材料涂层以改善细胞粘附性或作为显像剂用于肿瘤治疗。 [1]
体外:整联蛋白αvβ3在许多细胞类型包括内皮细胞、上皮细胞、成纤维细胞、成骨细胞和平滑肌细胞中表达。整联蛋白αvβ3在发生血管生成的内皮细胞中上调，肿瘤血管生成期间在内皮细胞中高表达。据报道, Cyclo (-RGDfK)对αvβ3 /αvβ5具有高亲和力，因此可以促进体外成骨细胞和软骨细胞的细胞粘附。[1,2]
体内:在兔子体内进行动物研究。据证实,新形成的骨组织与RGD-肽包被的植入物产生直接接触,而无包被的植入物似乎与新形成的骨组织分离。这种分离是由一种可阻断植入物和骨骼之间结合的纤维组织层引起。[3]
临床试验：目前尚未进行临床试验。
参考文献：
[1]Mas-Moruno C, Rechenmacher F and Kessler H. Cilengitide: the first anti-angiogenic small molecule drug candidate. design, synthesis and clinical evaluation. Anticancer Agents Med Chem. 2010; 10: 753-68.
[2]Hersel U, Dahmen C, Kessler H. RGD modified polymers: Biomaterials for stimulated cell adhesion and beyond. Biomaterials. 2003; 24: 4385-415.
[3]Schaffner P, Meyer J, Dard M, Wenz R, Nies B, Verrier S, Kessler H, Kantlehner M. Induced tissue integration of bone implants by coating with bone selective RGD-peptides in vitro and in vivo studies. J Mater Sci: Mater Med. 1999: 10: 837–9.
- 1. Alessandro Bortolami, Wei Yu, et al. "Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy." Cell Death Differ. 2023 Mar;30(3):687-701. PMID: 36207442
- 2. Yu W, Shin MR, et al. "Complexes formed with integrin-α5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticity via Ras and Akt signaling." FASEB J. 2019 Nov 2:fj201901792R. PMID: 31682765
- 3. Lee HN, Bosompra OA, et al. "RECK isoforms differentially regulate fibroblast migration by modulating tubulin post-translational modifications." Biochem Biophys Res Commun. 2019 Mar 5;510(2):211-218. PMID: 30704758
- 4. Lim C, Moon J, et al. "Cyclic RGD-conjugated Pluronic(?) blending system for active, targeted drug delivery." Int J Nanomedicine. 2018 Aug 10;13:4627-4639. PMID: 30127610
- 5. Schneider G, Suszynska M, et al. "Vitronectin in the Ascites of Human Ovarian Carcinoma Acts as a Potent Chemoattractant for Ovarian Carcinoma: Implication for Metastasis by Cancer Stem Cells[J]." Journal of Cancer Stem Cell Research, 2016, 4: e1005.
| Storage | Store at -20°C |
| M.Wt | 603.7 |
| Cas No. | 161552-03-0 |
| Formula | C27H41N9O7 |
| Synonyms | Cyclo(-Arg-Gly-Asp-D-Phe-Lys) |
| Solubility | ≥30.19 mg/mL in DMSO; insoluble in EtOH; ≥59.2 mg/mL in H2O |
| Chemical Name | 2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid |
| SDF | Download SDF |
| Canonical SMILES | C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=CC=C2)CC(=O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | Cyclo (-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin. | |||||
| Targets | Integrin | |||||
| IC50 | ||||||
质量控制和MSDS
- 批次:
化学结构
相关生物数据
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