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CU CPT 4a

 
Catalog No.
B5752
TLR3抑制剂
组合的产品项目
规格价格库存 数量
1mg
¥ 2,491.00
现货
5mg
¥ 6,987.00
现货

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A

背景

CU CPT 4a is a selective TLR3 inhibitor with IC50 of 3.44 μM in RAW 264.7 cells. It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells. It reduces the mortality of crypt cells in mice and reduces gastrointestinal syndrome.

References:

[1]. Cheng K, Wang X, Yin H. Small-Molecule Inhibitors of the TLR3/dsRNA Complex. Journal of the American Chemical Society, 2011, 133(11): 3764-3767.

[2]. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nature Communications, 2014, 5.

文献引用

化学属性

Physical AppearanceWhite solid
StorageStore at 4°C
M.Wt377.82
Cas No.1279713-77-7
FormulaC18H13ClFNO3S
Solubility<37.78mg/ml in DMSO
Chemical Name(R,Z)-2-(((3-chloro-6-fluorobenzo[b]thiophen-2-yl)(hydroxy)methylene)amino)-3-phenylpropanoic acid
SDFDownload SDF
Canonical SMILESClC(C1=C(S2)C=C(F)C=C1)=C2/C(O)=N/[C@](C(O)=O)([H])CC3=CC=CC=C3
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制

质量控制和MSDS

批次:

化学结构

CU CPT 4a