切换导航
关闭
  • 菜单
  • Setting

Colistin Methanesulfonate (sodium salt)

 
Catalog No.
C3046
抗生素粘菌素(也称为多粘菌素E)的前药
组合的产品项目
规格价格库存 数量
1g
¥ 2,163.00
Ship with 10-15 days
5g
¥ 9,709.00
Ship with 10-15 days

电话: 021-55669583

邮箱: sales@apexbio.cn

全球经销商

A

背景

Colistin methanesulfonate is an inactive prodrug of colistin (also known as polymyxin E), which is an antibiotic with effect against most Gram-negative bacteria, but also causes nephro- and neurotoxicity [1]. Colistin is produced by certain strains of the bacteria Paenibacillus polymyxa, and belongs to the class of polypeptide antibiotics known as polymyxins.

In Vitro: Studying the time-kill kinetics of Colistin methanesulfonate against a type culture of pseudomonas aeruginosa found that 8.0 or 32 mg/l Colistin methanesulfonate began killing at approximately 90 or 30 min, and the mean AUC0-240 values were 186.3±6.0 and 90.4±4.1, respectively [2]. Besides, by investigation among mucoid and nonmucoid strains of Pseudomonas aeruginosa isolated from patients with cystic fibrosis, Colistin methanesulfonate was found to require a concentration of 16 times the MIC to achieve complete killing within 24 h [3].

In Vivo: no data available.

Clinical trial: no data available.

References:
[1] Nation R L, Li J.  Colistin in the 21st century.[J]. Current Opinion in Infectious Diseases, 2009, 22(6): 535-543.
[2] Bergen P J, Li J, Rayner C R, et al.  Colistin methanesulfonate is an inactive prodrug of colistin against Pseudomonas aeruginosa.[J]. Antimicrobial Agents and Chemotherapy, 2006, 50(6): 1953-1958.
[3] Li J, Turnidge J D, Milne R W, et al.  In Vitro Pharmacodynamic Properties of Colistin and Colistin Methanesulfonate against Pseudomonas aeruginosaIsolates from Patients with Cystic Fibrosis[J]. Antimicrobial Agents and Chemotherapy, 2001, 45(3): 781-785.

化学属性

StorageStore at -20°C
M.Wt1749.8
Cas No.8068-28-8
FormulaC58H105N16O28S5·5Na
SynonymsColimycin M,Polymyxin E sodium methanesulfonate
Solubility≥53.9 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO
Chemical Namesodium (Z)-N-((6Z,9Z)-7,10-dihydroxy-8-(1-hydroxyethyl)-5-((Z)-oxido(((1Z,4E,7Z,10Z,13Z,16Z,19Z)-2,5,11,14-tetrahydroxy-3-(1-hydroxyethyl)-12,15-diisobutyl-8,17,20-trioxido-6,9,18-tris(2-((sulfomethyl)amino)ethyl)-1,4,7,10,13,16,19-heptaazacyclotricosa-1,
SDFDownload SDF
Canonical SMILESCCC(CCCC/C([O-])=N/C(/C(O)=N/C(/C(O)=N/C(/C([O-])=N/C(/C([O-])=N/C(/C([O-])=N/C(/C(O)=N/C(/C(O)=N/C(/C([O-])=N/C(/C(O)=N\1)CCNCS(O)(=O)=O)CCNCS(O)(=O)=O)CC(C)C)CC(C)C)CCNCS(O)(=O)=O)CC/N=C(O)/C1C(O)C)CCNCS(O)(=O)=O)C(O)C)CCNCS(O)(=O)=O)C.[Na+].[Na+].[Na+]
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

试验操作

细胞实验 [1]:

细胞系

铜绿假单胞菌

溶解方法

在H2O中的溶解度≥53.9mg/mL。为了获得更高的浓度,可以将离心管在37℃加热10分钟和/或在超声波浴中震荡一段时间。原液可以在-20℃以下储存几个月。

反应条件

0.5~1mg/l

应用

Colistin methanesulfonate的MIC范围为0.5 to 1 mg/l。此外,通过调查从囊性纤维化患者中分离出的铜绿假单胞菌的黏液样和非黏液样菌株,发现Colistin methanesulfonate需要16倍MIC浓度才能在24h内完全杀灭细菌。

References:

[1]. Lemaire S, Kosowska-Shick K, Appelbaum PC, Verween G, Tulkens PM, Van Bambeke F. Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. Antimicrob Agents Chemother. 2010 Jun;54(6):2549-59. doi: 10.1128/AAC.01724-09.Epub 2010 Apr 12. PubMed PMID: 20385852; PubMed Central PMCID: PMC2876393.

质量控制

质量控制和MSDS

批次:

化学结构

Colistin Methanesulfonate (sodium salt)