Prothrombin (474-477) [Mus musculus]
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
凝血酶原又称为凝血因子II，氨基酸序列为H2N-Tyr-Ile-His-Pro-OH，产生于肝脏，其翻译后修饰具有维生素K依赖性，将凝血酶原上的10位谷氨酸转变成γ-羧基谷氨酸（ GLA）。
在凝血级联反应中，凝血酶原经蛋白水解之后形成凝血酶，最终阻止失血过程。凝血酶反过来作为一个丝氨酸蛋白酶，将可溶性纤维蛋白原转变成不溶的纤维蛋白，催化许多其它相关的凝血反应[1]。
凝血酶原的激活在生理和病理凝血功能中至关重要。凝血酶原涉及许多罕见疾病，例如低凝血酶原血症。在自身免疫性疾病中，抗凝血酶原的抗体是引起狼疮抗凝物的一个因素，也被称为抗磷脂综合征。G20210A突变引起低凝血酶原血症，因此，控制凝血酶原是大多数抗凝血剂的核心作用方式。
参考文献：
1. Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL (May 1987). "Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somat. Cell Mol. Genet. 13 (3): 285–92.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 528.6 |
| Formula | C26H36N6O6 |
| Synonyms | H2N-Tyr-Ile-His-Pro-OH |
| Solubility | insoluble in H2O; ≥19 mg/mL in EtOH; ≥52.9 mg/mL in DMSO |
| SDF | Download SDF |
| Canonical SMILES | OC1=CC=C(C[C@H](N)C(N[C@@H]([C@H](C)CC)C(NC(CC2=CNC=N2)C(N3CCC[C@]3([H])C(O)=O)=O)=O)=O)C=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
![Coagulation factor II peptide; prothrombin (474-477) [Mus musculus]](http://www.apexbt.com//media/diy/images/struct/A1058.png)