CNX-774
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
CNX-774是口服有效的BTK选择性抑制剂,其IC50值小于1 nM.
布鲁顿氏酪氨酸激酶(BTK)是B细胞抗原受体(BCR)信号传导途径中的重要酶,在肥大细胞活化以及B细胞成熟中起着重要作用.
CNX-774是一种口服有效的\不可逆的和选择性的BTK抑制剂,其IC50值小于1 nM.CNX-774与BTK的ATP结合位点的Cys481残基形成共价键.在细胞实验中,CNX-774抑制BTK,其IC50值为1 ~ 10 nM[1].
参考文献:
[1]. Akinleye A, Chen Y, Mukhi N, et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol, 2013, 6: 59.
Storage | Store at -20°C |
M.Wt | 499.5 |
Cas No. | 1202759-32-7 |
Formula | C26H22FN7O3 |
Solubility | Soluble in DMSO |
Chemical Name | 4-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]-N-methylpyridine-2-carboxamide |
SDF | Download SDF |
Canonical SMILES | CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)F |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |