CNQX
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
CNQX is a potent and competitive antagonist for AMPA/kainate receptors.
Superfusion of hippocampal slices and CNQX (2-5 μM) reversibly blocks Schaffer collaterals and mossy fiber excitatory post-synaptic potentials (EPSP), and also retains fast and slow GABA-mediated inhibitory effects[1].
Ten minutes before the test, CNQX (0.5 or 1.25 μg) is bilaterally infused into the amygdala or dorsal hippocampus, which partially prevented the expression of hypotensive avoidance in rats at 24 h after training. At a dose of 0.5 μg, CNQX causes complete blockade[2].
References:
[1]. Neuman R S, Ben-Ari Y, Gho M, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro. Neuroscience Letters, 1988, 92(1): 64-68.
[2]. Kim M, Campeau S, Falls W A, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol, 1993, 59(1): 5-8.
| Physical Appearance | A solid |
| Storage | Store at RT |
| M.Wt | 232.16 |
| Cas No. | 115066-14-3 |
| Formula | C9H4N4O4 |
| Solubility | ≥23.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | 7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile |
| SDF | Download SDF |
| Canonical SMILES | O=C1NC2=CC([N+]([O-])=O)=C(C#N)C=C2NC1=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
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