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CMX001

现货
Catalog No.
B1089
广谱抗病毒药物
组合的产品项目
规格价格库存 数量
5mg
¥ 6,000.00
现货
25mg
¥ 18,000.00
现货

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Background

CMX001 is a broad spectrum antiviral agent [1].

CMX001 has been reported to be active in vitro against a broad range of viruses from all five families of dsDNA viruses infecting human with EC50 values of 0.02μM, 0.0004μM, 17μM , 0.045μM and 0.07μM for Adenovirus, Herpesvirus, Papillomavirus, Polyomavirus and Orthopoxvirus, respectively. In addition, CMX001 has been revealed to arrest disease progression by inhibiting viral DNA replication and thereby reducing viral burden. Apart from these, initial studies has been demonstrated the efficacy of CMX001 for pre-exposure and post-exposure prophylaxis in mouse, rabbit, cynomolgus monkeys and human [1].

References:
[1]Lanier R1, Trost L, Tippin T, Lampert B, Robertson A, Foster S, Rose M, Painter W, O'Mahony R, Almond M, Painter G.Development of CMX001 for the Treatment of Poxvirus Infections. Viruses. 2010 Dec; 2(12):2740-2762.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt561.69
Cas No.444805-28-1
FormulaC27H52N3O7P
Solubility<1.12mg/mL in DMSO, Limited solubility in EtOH
Chemical Name[(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic acid
SDFDownload SDF
Canonical SMILESCCCCCCCCCCCCCCCCOCCCOP(=O)(COC(CN1C=CC(=NC1=O)N)CO)O
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

试验操作

细胞实验[1]:

细胞系

人胎脑SVG细胞

溶解方法

在DMSO中的溶解度大于10 mM。为了获得更高的浓度,可以将离心管在37℃加热10分钟和/或在超声波浴中震荡一段时间。原液可以在-20℃以下储存几个月。

反应条件

0.01,0.03,0.07,0.1和1 μM,96 h

应用

在感染初期,CMX001导致感染JCV的细胞数量剂量依赖性降低。此外,CMX001处理导致感染细胞中的JCV基因组拷贝数剂量依赖性降低。

动物实验[2]:

动物模型

4-6周龄的雌性A/Ncr小鼠

剂量

口服给药,第0天10 mg/kg,此后每隔一天给药2.5 mg/kg

应用

CMX001以10 mg/kg的剂量给药小鼠,然后每隔一天给药2.5 mg/kg,持续两周,对小鼠鼻内感染鼠痘病毒后的死亡率和体重减轻提供了有力的保护。

注意事项

请测试所有化合物在室内的溶解度,实际溶解度和理论值可能略有不同。这是由实验系统的误差引起的,属于正常现象。

References:

[1]. Jiang Z G, Cohen J, Marshall L J, et al. Hexadecyloxypropyl-cidofovir (CMX001) suppresses JC virus replication in human fetal brain SVG cell cultures[J]. Antimicrobial agents and chemotherapy, 2010, 54(11): 4723-4732.

[2]. Parker S, Touchette E, Oberle C, et al. Efficacy of therapeutic intervention with an oral ether–lipid analogue of cidofovir (CMX001) in a lethal mousepox model[J]. Antiviral research, 2008, 77(1): 39-49.

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