Chidamide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Chidamide是一种新型的苯甲酰胺型组蛋白去乙酰化酶(HDAC)抑制剂.现已研究了CS055对人白血病细胞系以及原代髓系白血病细胞增殖\分化以及凋亡的作用[1].
组蛋白去乙酰化酶(HDACs)由一系列酶组成,可以使组蛋白氨基末端赖氨酸残基乙酰化和去乙酰化,从而导致染色质结构重塑,影响染色质结合转录因子,最终启动基因转录[2].
Chidamide影响细胞周期.在不同p53状态的BEL-7402和HCC-9204细胞中,Chidamide显著降低S期细胞比例,而显着增加G1期细胞比例.随着剂量增加,Chidamide显著改变处于不同细胞周期的细胞数量[2].
研究结果表明,在人白血病细胞中,Chidamide抑制细胞增殖\诱导细胞分化与凋亡,是一种新型的有望用于治疗几种血液学恶性肿瘤的HDAC抑制剂[1].
参考文献:
[1] Gong K, Xie J, Yi H, Li W. CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosisand differentiation in human leukaemia cells. Biochem J. 2012 May 1;443(3):735-46.
[2] Wang H1, Guo Y, Fu M, Liang X, etal. , Antitumor activity of Chidamide in hepatocellular carcinoma cell lines. Mol Med Rep. 2012 Jun;5(6):1503-8.
- 1. Yi Que , Xiao-Long Zhang, et al. "Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma." J Immunother Cancer. 2021 Feb;9(2):e001696. PMID:33637599
- 2. Li Z, Luo J. "Research on epigenetic mechanism of SFRP2 in advanced chronic myeloid leukemia." Biochem Biophys Res Commun. 2018 Jun 18;501(1):64-72. PMID:29704505
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 390.41 |
Cas No. | 743420-02-2 |
Formula | C22H19FN4O2 |
Solubility | insoluble in H2O; insoluble in EtOH; ≥18.55 mg/mL in DMSO |
Chemical Name | N-(2-amino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide |
SDF | Download SDF |
Canonical SMILES | FC1=CC(NC(C2=CC=C(CNC(C=CC3=CC=CN=C3)=O)C=C2)=O)=C(N)C=C1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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