CGS 21680 HCl
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
CGS 21680 HCl是腺苷A2受体的选择性激动剂,其IC50值为22 nM[1].
在大鼠纹状体膜中,CGS21680有效地抑制配体结合腺苷A2受体,其IC50值为22 nM.在结合试验中,CGS21680对脑膜上假定的其它神经递质/神经调质位点无效,如肾上腺素\多巴胺以及血清素.在大鼠心脏模型中,CGS21680有效地增加冠脉血流量,其EC25值为2 nM[1].
在麻醉的正常血压大鼠中,CGS 21680 HCl有效地降低血压,其ED50值为9 μg/kg.CGS 21680 HCl也可以引起心率加快(高达15%).此外,10 mg/kg CGS 21680 HCl显著降低自发性高血压大鼠的血压.于给药30分钟后,可以观察到该模型的心率瞬间升高[1].
参考文献：
[1] Hutchison A J, Webb R L, Oei H H, et al. CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity. Journal of Pharmacology and Experimental Therapeutics, 1989, 251(1): 47-55.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 535.98 |
| Cas No. | 124431-80-7 |
| Formula | C23H30ClN7O6 |
| Solubility | ≥53.6 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | 3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CCNC(=O)C1C(C(C(O1)N2C=NC3=C2N=C(N=C3N)NCCC4=CC=C(C=C4)CCC(=O)O)O)O.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
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化学结构
