CGP 35348
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
CGP 35348是一种选择性的γ氨基丁酸B(GABAB)受体拮抗剂,IC50值为34 μM[1].
GABAB受体是一种GABA的代谢型跨膜受体,通过G蛋白与钾离子通道相连.GABAB受体刺激K +通道的开放并超极化神经元.
CGP 35348是一种选择性的GABAB受体拮抗剂,可以穿透血脑屏障.在大鼠皮层切片中,CGP 35348抑制L-baclofen对去甲肾上腺素刺激的腺苷酸环化酶的增强作用.海马切片中,CGP 35348(10\30\100 μM)抑制L-baclofen(10 μM)诱导的膜超极化和抑制性突触后电位[1].
在大鼠脊髓中,CGP 35348(3-30 μg)剂量依赖性地抑制L- baclofen诱导的镇痛作用[2].在大鼠中,CGP 35348剂量依赖性地诱导对机械刺激的疼痛样反应,并减少压力诱导的爪缩回阈值[3].在大鼠中,CGP 35348(500 mg/kg)通过阻断中央GABAB受体显著减少食物消耗[4].
参考文献:
[1]. Olpe HR, Karlsson G, Pozza MF, et al. CGP 35348: a centrally active blocker of GABAB receptors. Eur J Pharmacol, 1990, 187(1): 27-38.
[2]. Hammond DL, Washington JD. Antagonism of L-baclofen-induced antinociception by CGP 35348 in the spinal cord of the rat. Eur J Pharmacol, 1993, 234(2-3): 255-262.
[3]. Hao JX, Xu XJ, Wiesenfeld-Hallin Z. Intrathecal gamma-aminobutyric acidB (GABAB) receptor antagonist CGP 35348 induces hypersensitivity to mechanical stimuli in the rat. Neurosci Lett, 1994, 182(2): 299-302.
[4]. Patel SM, Ebenezer IS. The effects of intraperitoneal and intracerebroventricular administration of the GABAB receptor antagonist CGP 35348 on food intake in rats. Eur J Pharmacol, 2004, 503(1-3): 89-93.
Physical Appearance | A white to off-white solid |
Storage | Store at 4°C |
M.Wt | 225.22 |
Cas No. | 123690-79-9 |
Formula | C8H20NO4P |
Solubility | Soluble in H2O |
Chemical Name | (S)-(3-aminopropyl)(diethoxymethyl)phosphinic acid |
SDF | Download SDF |
Canonical SMILES | O[P@@](CCCN)(C(OCC)OCC)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |