CGP 3466B maleate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
R-(2)-Deprenyl是用于治疗帕金森氏病的药物之一.它的神经保护作用以及对细胞凋亡的抑制机制仍未研究清楚.CGP 3466是R-(2)-Deprenyl结构相关的类似物,几乎没有单胺氧化酶B型抑制活性,但具有神经保护作用.
体外实验:CGP 3466B在结构上与传统的单胺氧化酶抑制剂和三环抗抑郁剂相关,但缺乏抗抑郁作用相关的药理学性质.在体外实验中,CGP 3466B可以防止人类神经母细胞瘤和PC-12细胞的凋亡性死亡以及保护小脑颗粒细胞免受阿糖胞苷诱导的死亡[1].
在体实验:在pmn/pmn小鼠中,出生后2周临床症状发作时口服CGP 3466B.CGP 3466B减缓疾病进展,增加57％寿命,维持体重和运动性能.CGP 3466B可以作为潜在的运动神经元疾病的治疗药物[2].
临床试验:到现在为止,CGP 3466B还处于临床前开发阶段.
参考文献：
[1] Kragten E,Lalande I,Zimmermann K,Roggo S,Schindler P,Muller D,van Oostrum J,Waldmeier P,Furst P. Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl. J Biol Chem.1998 Mar 6;273(10):5821-8.
[2] Sagot Y,Toni N,Perrelet D,Lurot S,King B,Rixner H,Mattenberger L,Waldmeier PC,Kato AC. An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease. Br J Pharmacol.2000 Oct;131(4):721-8.
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 391.42 |
| Cas No. | 200189-97-5 |
| Formula | C19H17NO·C4H4O4 |
| Solubility | Soluble in DMSO |
| Chemical Name | N-(dibenzo[b,f]oxepin-10-ylmethyl)-N-methylprop-2-yn-1-amine maleate |
| SDF | Download SDF |
| Canonical SMILES | CN(CC#C)CC1=CC2=CC=CC=C2OC3=CC=CC=C13.OC(/C=C\C(O)=O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
