Cefoselis
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cefoselis是一种广泛应用的β内酰胺抗生素[1]。
Cefoselis对革兰氏阳性细菌具有广泛的抗菌谱。该物质是第4代头孢菌素。Cefoselis有一些副作用,如在老人和肾功能衰竭病人中可引起惊厥和抽搐。通过HPLC检测透析液和血样,cefoselis剂量依赖地出现在纹状体透析液样本中,但在细胞外液中迅速消失。在肾衰竭大鼠中,cefoselis的清除半衰期延长。这可能是头孢噻利引发惊厥的因素。此外,在海马体中使用cefoselis可引起细胞外谷氨酸增加及GABA轻微增加,表明cefoselis通过阻断GABA受体引起惊厥[1]。
参考文献:
[1] Ohtaki K, Matsubara K, Fujimaru S, Shimizu K, Awaya T, Suno M, Chiba K, Hayase N, Shiono H. Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. J Neural Transm. 2004 Dec;111(12):1523-35.
Storage | Store at -20°C |
M.Wt | 522.56 |
Cas No. | 122841-10-5 |
Formula | C19H22N8O6S2 |
Solubility | Soluble in DMSO |
Chemical Name | (6R,7R)-3-[[3-amino-2-(2-hydroxyethyl)pyrazol-1-ium-1-yl]methyl]-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
SDF | Download SDF |
Canonical SMILES | CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=C(N4CCO)N)C(=O)[O-] |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
动物实验 [1]: | |
动物模型 |
雄性Wistar大鼠 |
剂量 |
10、50和400 mg/kg(i.v.) |
应用 |
Cefoselis呈剂量依赖性地出现在脑细胞外液中,与血液中浓度成比例。脑细胞外液(表观)的消除常数略低于血液。在肾功能不全的大鼠中,cefoselis从血液和大脑中消除的半衰期大大延长。 |
注意事项 |
请测试所有化合物在室内的溶解度,实际溶解度和理论值可能略有不同,这是由实验系统的误差引起的,属于正常现象。 |
References: [1]. Ohtaki K, Matsubara K, Fujimaru S, Shimizu K, Awaya T, Suno M, Chiba K, Hayase N, Shiono H. Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. J Neural Transm (Vienna). 2004 Dec;111(12):1523-35. Epub 2004 Jul 7. PubMed PMID:15565489. |
Description | Cefoselis是一种广泛应用的β内酰胺抗生素。 | |||||
靶点 | β-lactam | |||||
IC50 |