Cefoperazone
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cefoperazone是一种头孢菌素抗生素,用于抑制rMrp2介导的[3H]E217βG摄取,IC50为199 μM[1]。
Cefoperazone的抑制曲线是双相的,IC50, high和IC50, low分别为6.66 ± 3.23 μM和3.88 ± 1.32 mM,表明cefoperazone可抑制介导[3H]E217βG转运的两个结合位点[1]。Cefoperazone是用于静脉内或肌内给药的无菌、半合成、广谱肠胃外头孢菌素抗生素。在静脉内给予2 g cefoperazone后,血清中的范围为202 μg/mL至375 μg/mL,这取决于给药的时间。肌内注射2 g cefoperazone后,在1.5小时平均峰值血清水平为111 μg/mL。在给药后12小时,平均血清水平为2至4 μg/mL。Cefoperazone与90%血清蛋白结合,表观分布容积为10至13 L,药物的半衰期为1.6到2.4小时,血清清除率在75和96 ml/min之间[2]。
参考文献:
[1]. Kato Y1,Takahara S,Kato S,Kubo Y,Sai Y,Tamai I,Yabuuchi H,Tsuji A. Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of beta-lactam antibiotics. Drug Metab Dispos.2008 Jun;36(6):1088-96. doi: 10.1124/dmd.107.019125. Epub 2008 Mar 13.
[2]. Craig WA,Gerber AU. Pharmacokinetics of cefoperazone: a review. Drugs.1981;22 Suppl 1:35-45.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 645.66 |
Cas No. | 62893-19-0 |
Formula | C25H27N9O8S2 |
Solubility | ≥64.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
Chemical Name | (6R,7R)-7-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
SDF | Download SDF |
Canonical SMILES | CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=C(C=C2)O)C(=O)NC3C4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)C(=O)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
动物实验 [1]: | |
动物模型 |
雄性Male Sprague-Dawley大鼠(SDRs) |
剂量 |
20 mg/kg(i.v.) |
应用 |
与SDRs相比,EHBRs中的cefoperazone血浆消失延迟了,且EHBRs中cefoperazone的CLtotal明显更低,平均停留时间更长。 |
注意事项 |
请测试所有化合物在室内的溶解度,实际溶解度和理论值可能略有不同,这是由实验系统的误差引起的,属于正常现象。 |
References: [1]. Kato Y, Takahara S, Kato S, Kubo Y, Sai Y, Tamai I, Yabuuchi H, Tsuji A. Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of beta-lactam antibiotics. Drug Metab Dispos. 2008 Jun;36(6):1088-96. doi: 10.1124/dmd.107.019125. Epub 2008 Mar 13. PubMed PMID: 18339814. |
质量控制和MSDS
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