Cefdinir
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 395.41 |
| Cas No. | 91832-40-5 |
| Formula | C14H13N5O5S2 |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥19.55 mg/mL in DMSO |
| Chemical Name | (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | C=CC1=C(N2C(C(C2=O)NC(=O)C(=NO)C3=CSC(=N3)N)SC1)C(=O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 动物实验 [1]： | |
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动物模型 |
急性肾损伤雄性Wistar大鼠模型 |
|
剂量 |
10 mg/kg (p.o.) |
|
应用 |
Cisplatin给药后，在第6天给大鼠口服cefdinir。可以观察到，与对照组相比，cefdinir的血浆暴露量显着增加。同时，cisplatin诱导的AKI组的累积尿排泄明显减少。可以估计病态可以显着影响cefdinir的体内释放。这些结果表明，在cisplatin诱导的AKI条件下，cefdinir的药代动力学发生了显着变化。 |
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注意事项 |
请测试所有化合物在室内的溶解度，实际溶解度和理论值可能略有不同，这是由实验系统的误差引起的，属于正常现象。 |
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References: [1]. Wang H, Sun P, Wang C, Meng Q, Liu Z, Huo X, Sun H, Ma X, Peng J, Liu K. Pharmacokinetic changes of cefdinir and cefditoren and its molecular mechanisms in acute kidney injury in rats. J Pharm Pharmacol. 2018 Nov;70(11):1503-1512. doi: 10.1111/jphp.12994. Epub 2018 Jul 25. PMID: 30047127. |
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质量控制和MSDS
- 批次:
化学结构
