CC-401
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
CC-401是一种JNK特异性抑制剂,其Ki值范围为25 ~ 50 nM[1].
CC-401是第二代ATP竞争性JNK抑制剂,对所有3种形式的JNK均显效.相对于其它激酶,如p38\ERK\IKK2和ZAP70,CC-401对JNK具有选择性.在基于细胞的试验中,1 ~ 5 μM CC-401有效抑制JNK.据发现,JNK信号激活发生在许多免疫介导的肾脏疾病模型中.因此,CC-401作为一种JNK抑制剂,在这些肾损伤模型中是有效的.在急性抗肾小球基底膜疾病中,CC-401可以抑制JNK活化并减少50% ~ 70%蛋白尿.此外,CC-401也被用于肝损伤模型[1 ~ 3].
参考文献：
[1] Ma F Y, Flanc R S, Tesch G H, et al. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. Journal of the American Society of Nephrology, 2007, 18(2): 472-484.
[2] Flanc R S, Ma F Y, Tesch G H, et al. A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis. Kidney international, 2007, 72(6): 698-708.
[3] Bogoyevitch M A, Arthur P G. Inhibitors of c-Jun N-terminal kinases—JuNK no more Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2008, 1784(1): 76-93.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 388.47 |
| Cas No. | 395104-30-0 |
| Formula | C22H24N6O |
| Solubility | ≥19.4 mg/mL in DMSO; ≥2.32 mg/mL in EtOH with ultrasonic; ≥8.7 mg/mL in H2O |
| Chemical Name | 3-[3-(2-piperidin-1-ylethoxy)phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole |
| SDF | Download SDF |
| Canonical SMILES | C1CCN(CC1)CCOC2=CC=CC(=C2)C3=NNC4=C3C=C(C=C4)C5=NC=NN5 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
