CAY10505
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
CAY10505是一种有效的PI3Kγ选择性抑制剂(IC50= 30 nM).
PI3K(磷脂酰肌醇-4,5-二磷酸-3-激酶)是一类参与细胞功能如细胞生长\增殖\分化\运动\存活和胞内运输的酶,从而参与癌症.该物质在PI3K/Akt/mTOR途径中扮演关键角色.
在经3.5 μM的BA处理的神经元中,CAY10505可部分降低黄芩素诱导的Akt磷酸化.[1]
在高血压大鼠中,0.6 mg.kg-1 p.o.的CAY10505具有如下效果:1)有效降低MABP;2)结合DOCA显著改善高血压大鼠血管内皮功能紊乱;3)显著提高血浆亚硝酸盐和/或硝酸盐浓度;4)防止高血压诱导的ACh诱导内皮依赖松弛的衰减.[2]
参考文献:
[1] Tyagi S, Sharma S, Budhiraja RD. Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats. Can J Physiol Pharmacol. 2012 Jul;90(7):881-5.
[2] Sun YY, Lin SH, Lin HC et al. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. PLoS One. 2013 Jul 19;8(7):e69019.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 289.28 |
Cas No. | 1218777-13-9 |
Formula | C14H8FNO3S |
Solubility | insoluble in EtOH; insoluble in H2O; ≥14.45 mg/mL in DMSO |
Chemical Name | (5E)-5-[[5-(4-fluorophenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione |
SDF | Download SDF |
Canonical SMILES | C1=CC(=CC=C1C2=CC=C(O2)C=C3C(=O)NC(=O)S3)F |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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