(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane, also known as trans-BTP Dioxolane, is a PAF receptor antagonist [1].
Platelet activating factor (PAF), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages. PAF play important roles in a variety of pathophysiological states including acute allergy, inflammation, asthma, gastrointestinal ulceration, and toxic shock [1].
(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane is a PAF receptor antagonist. In the rabbit washed platelet assay, (±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane showed good competitive PAF antagonism with Ki value of 0.3 μM, whereas the cis-isomer was much less active.
Reference:
[1]. Corey, E.J.,Chen, C.P., and Parry, M.J. Dual binding modes to the receptor for platelet activating factor (PAF) of anti-PAF trans-2,5-diarylfurans. Tetrahedron Letters 29, 2899-2902 (1988).
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 406.4 |
Cas No. | 116673-45-1 |
Formula | C21H26O8 |
Synonyms | trans-BTP Dioxolane |
Solubility | ≤35mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide |
Chemical Name | trans-(±)-2,4-bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane |
SDF | Download SDF |
Canonical SMILES | COC1=CC([C@H]2O[C@H](C3=CC(OC)=C(OC)C(OC)=C3)OC2)=CC(OC)=C1OC |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |