Rimantadine Hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Rimantadine hydrochloride is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.
In a variety of tissue culture systems, rimantadine (25 μg/ml) completely suppressed the growth of dengue virus type 2 in human peripheral blood leukocytes (PBL). Rimantadine significantly inhibited dengue virus replication in cultures of rhesus monkey PBL. In virus-infected LLC-MK2 cell cultures, rimantadine decreased the production of all four types of dengue virus [1]. Rimantadine interfered with the generation of cellular immune responses. Rimantadine hydrochloride inhibited the proliferative response of human peripheral blood lymphocytes to mitogenic and antigenic stimulation. Rimantadine hydrochloride (25 μg/ml) suppressed the responses to phytohemagglutinin, pokeweed mitogen, and concanavalin A by 25, 65, and 90%, respectively. rimantadine (10 μg/ml) significantly inhibited responses to streptokinase-streptodornase, tetanus toxoid, and A2/Aichi influenza vaccine [2]. In a randomized, double-blind trial involving patients with uncomplicated influenza A H3N2 subtype virus infection, rimantadine (200 mg/day for 5 days) significantly reduced nasal secretion viral titers (days 2 through 4), maximal temperature (days 2 and 3), time until defervescence (mean, 37 h shorter), and systemic symptoms [3].
References:
[1] Koff W C, Elm Jr J L, Halstead S B. Suppression of dengue virus replication in vitro by rimantadine hydrochloride[J]. The American journal of tropical medicine and hygiene, 1981, 30(1): 184-189.
[2] Koff W C, Peavy D L, Knight V. Inhibition of in vitro proliferative responses of human lymphocytes by rimantadine hydrochloride[J]. Infection and immunity, 1979, 23(3): 665-669.
[3] Hayden F G, Monto A S. Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults[J]. Antimicrobial agents and chemotherapy, 1986, 29(2): 339-341.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 215.76 |
Cas No. | 1501-84-4 |
Formula | C12H22ClN |
Solubility | ≥21.6 mg/mL in DMSO; ≥9.24 mg/mL in H2O; ≥9.88 mg/mL in EtOH |
Chemical Name | (R)-1-((1s,3R,5S,7S)-adamantan-1-yl)ethanamine hydrochloride |
SDF | Download SDF |
Canonical SMILES | CC(C12CC3CC(C1)CC(C3)C2)N |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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