Hexanolamino PAF C-16
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Hexanolamino PAF C-16 is a PAF analog with PAF agonist/antagonist properties.
Platelet activating factor (PAF; C16), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages [1].
Hexanolamino PAF C-16, a PAF analog with an increased inter-ionic distance in the polar head group, showed a greater potency in macrophages than platelets. In human monocyte-derived macrophages, Hexanolamino PAF C-16 was an antagonist and specifically inhibited the generation of superoxide ion (02-) and hydrogen peroxide (H202) in response to PAF [1]. In both rabbit platelets and guinea-pig macrophages, Hexanolamino PAF C-16 acted as a partial agonist [2].
References:
[1]. Rouis M, Nigon F, Chapman MJ. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. Biochem Biophys Res Commun. 1988 Nov 15;156(3):1293-301.
[2]. Stewart AG, Grigoriadis G. Structure-activity relationships for platelet-activating factor (PAF) and analogues reveal differences between PAF receptors on platelets and macrophages. J Lipid Mediat. 1991 Nov;4(3):299-308.
| Physical Appearance | A lyophilized powder |
| Storage | Store at -20°C |
| M.Wt | 579.8 |
| Cas No. | 137566-83-7 |
| Formula | C30H62NO7P |
| Solubility | ≤23mg/ml in ethanol;0.5mg/ml in DMSO;1.5mg/ml in dimethyl formamide |
| Chemical Name | 1-O-hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphoryl(N,N,N-trimethyl)hexanolamine |
| SDF | Download SDF |
| Canonical SMILES | CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP(OCCCCCC[N+](C)(C)C)([O-])=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
