Cetaben
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cetaben is an unique PPARα-independent peroxisome proliferator.
The fibrate class of hypolipidemic drugs, such as fenofibrate and clofibrate, elicit their effects via binding to and activating peroxisome proliferator-activated receptor α (PPARα).
In vitro: Previous study showed that cetaben could cause little but reversible proliferation and morphological heterogeneity with the occurrence of dumbbell- and cup-shaped peroxisomal profiles. Peroxisomes in HepG2 cells showed marked variation in size and shape. Cetaben treatment of HepG2 cells was able to lead to disintegration of Golgi regions and augmented mitochondrial matrix [1].
In vivo: Animal study found that the changes in large scale of liver non-peroxisomal parameters were compared after 10 days administration of both cetaben and clofibric acid 200 mg/kg/day to male Wistar rats. No analogical changes were observed after cetaben treatment in the livers of experimental animals. It was also found that both drugs could increase the activities of alanine-glyoxylate aminotransferase-1 and acetylcarnitine transferase--enzymes with proven mitochondrial and peroxisomal location. Contrary to clofibric acid, cetaben did not increase solubilization of peroxisomal enzymes [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Kovacs, W. ,Walter, I., and Stangl, H. Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatoma and HepG2 human hepatoblastoma cells. Histochemistry and Cell Biology 115, 509-519 (2001).
[2] Chandoga, J. ,Hampl, L.,Turecky, L., et al. Cetaben is an exceptional type of peroxisome proliferator. International Journal of Biochemistry 26(5), 679-696 (1994).
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 361.6 |
Cas No. | 55986-43-1 |
Formula | C23H39NO2 |
Synonyms | Hexadecylamino-p-amino Benzoic Acid |
Solubility | ≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
Chemical Name | 4-(hexadecylamino)-benzoic acid |
SDF | Download SDF |
Canonical SMILES | CCCCCCCCCCCCCCCCNC1=CC=C(C(O)=O)C=C1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |