1H-1-ethyl Candesartan Cilexetil
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
1H-1-ethyl Candesartan Cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist.
Angiotensin II is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including AT1[1]. AT1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. Furthermore, AT1 mediates the classical biological actions of angiotensin II. Also, AT1 has seven helical transmembrane domains, which is the characteristic of the superfamily of G-protein-coupled receptors. Carboxyl-terminal region structure of AT1 plays important roles in receptor internalization, desensitization and phosphorylation [2].
In vitro: Up to now, in vitro study of 1H-1-ethyl candesartan cilexetil is still in the development stage.
In vivo: Up to now, in vivo study of 1H-1-ethyl candesartan cilexetil is still in the development stage.
References:
[1]. Otsuka, M. Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist. Thorax. 2004; 59(1): 31-38.
[2]. GUO, D., SUN, Y., HAMET, P., & INAGAMI, T. The angiotensin II type 1 receptor and receptor-associated proteins. Cell Research. 2001; 11(3): 165-180.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 638.7 |
Cas No. | 914613-35-7 |
Formula | C35H38N6O6 |
Solubility | ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide |
Chemical Name | 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester |
SDF | Download SDF |
Canonical SMILES | O=C(OC(C)OC(C1=C(N(CC2=CC=C(C3=C(C4=NN=NN4CC)C=CC=C3)C=C2)C(OCC)=N5)C5=CC=C1)=O)OC6CCCCC6 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |