(R,S)-Anatabine (tartrate)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Anatabine is a minor tobacco alkaloid with a chemical structural similarity to nicotine. Anatabine is produced in plants of the Solanacea family including tobacco, green tomatoes, peppers and eggplants [1]. Anatabine is an Aβ inhibitor [1]. (R,S)-Anatabine (tartrate) is preferable to (R,S)-Anatabine for certain applications and formulations.
Aβ peptides play a dominant role in the development of Alzheimer's disease. Natural soluble Aβ oligomers and more specifically Aβ dimers isolated from Alzheimer's disease brains have been involved in inducing tau hyperphosphorylation and neuritic degeneration, which results in the accumulation of Aβ oligomers to the neurofibrillary degeneration observed in Alzheimer's disease (AD) [1].
In vitro: Anatabine dose-dependently lowered Aβ1-40 and Aβ1-42 levels and reduced sAPPβ production without any effects on sAPPα levels. Anatabine lowered Aβ production by mainly impacting the β-cleavage of APP. Anatabine lowered NFκB activation. Anatabine inhibited BACE-1 transcription and reduced BACE-1 protein levels in human neuronal like SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-κB activation [1].
In vivo: In a transgenic mouse model with AD, treatment with anatabine for 4 days remarkably lowered brain soluble Aβ1-40 and Aβ1-42 levels [1].
Reference:
[1] Paris D, Beaulieu-Abdelahad D, Bachmeier C, et al. Anatabine lowers Alzheimer's Aβ production in vitro and in vivo[J]. European journal of pharmacology, 2011, 670(2): 384-391.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 310.3 |
Formula | C10H12O2·C4H6O6 |
Solubility | ≤1mg/ml in ethanol;20mg/ml in DMSO;33mg/ml in dimethyl formamide |
Chemical Name | 1,2,3,6-tetrahydro-2,3'-bipyridine 2,3-dihydroxysuccinate |
SDF | Download SDF |
Canonical SMILES | OC(C(O)C(O)=O)C(O)=O.C1(C2=CN=CC=C2)CC=CCN1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |