GSK2881078
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
GSK2881078 is a potent and selective androgen receptor modulator (SARM) [1].
Steroidal nuclear receptor (NR) ligands play important roles in the health of both men and women. Dihydrotestosterone (DHT) and testosterone (T) are endogenous steroidal ligands for the androgen receptor (AR) that play a role in every tissue type found in the mammalian body. During the development of the fetus, androgens play an important role in sexual differentiation and development of male sexual organs. SARMs are small molecule pharmacotherapeutics that have the potential to afford the important benefits of androgen therapy without the undesired side-effects [1].
GSK2881078 is a potent and selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting to improve their physical function. GSK2881078 is currently in phase I clinical trials [1].
Reference:
[1]. https://newdrugapprovals.org/2016/06/14/gsk-2881078/
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 330.3 |
| Cas No. | 1539314-06-1 |
| Formula | C14H13F3N2O2S |
| Solubility | ≤20mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide |
| Chemical Name | 1-[(1R)-1-methyl-2-(methylsulfonyl)ethyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile |
| SDF | Download SDF |
| Canonical SMILES | CS(C[C@@H](C)N1C2=CC=C(C#N)C(C(F)(F)F)=C2C=C1)(=O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
