ATB-337
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac [1].
Hydrogen sulfide (H2S) is a newly recognized signaling molecule with potent cytoprotective actions. Hydrogen sulfide has been involved in mediating many physiological processes, such as the maintenance of gastrointestinal mucosal defense and repair. Hydrogen sulfide also exerts many anti-inflammatory effects, including inhibition of leukocyte adherence to the vascular endothelium and leukocyte migration to sites of inflammation [2].
Oral administration of ATB-337 did not produce any hemorrhagic erosions. Oral administration of an equimolar dose of ATB-337 produced > 90% less small intestinal damage and showed no significant effect on the hematocrit. In rats, administration of ATB-337 (50 μmol/kg) showed no significant effect on leukocyte adherence. Oral administration of ATB-337 significantly increased plasma levels of H2S by > 40%. In a rat air pouch model, ATB-337 (1 μmol/kg) suppressed COX-2 activity. In the rat, ATB-337 inhibited thromboxane synthesis. ATB-337 suppressed arachidonic acid–induced human platelet aggregation. Pretreatment with ATB-337 (10 μmol/kg) reduced paw swelling. ATB-337 generated ~12nmol/min of H2S when it was incubated in buffer.
References:
[1] Wallace J L, Caliendo G, Santagada V, et al. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide–releasing diclofenac derivative in the rat[J]. Gastroenterology, 2007, 132(1): 261-271.
[2] Wallace J L. Physiological and pathophysiological roles of hydrogen sulfide in the gastrointestinal tract[J]. Antioxidants & redox signaling, 2010, 12(9): 1125-1133.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 504.5 |
Cas No. | 912758-00-0 |
Formula | C23H15NCl2O2S3 |
Synonyms | ACS 15,S-Diclofenac |
Solubility | ≤10mg/ml in DMSO;10mg/ml in dimethyl formamide |
Chemical Name | 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester |
SDF | Download SDF |
Canonical SMILES | O=C(Oc1ccc(cc1)c1ssc(=S)c1)Cc1ccccc1Nc1c(Cl)cccc1Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)