15-acetoxy Scirpenol
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
15-acetoxy Scirpenol is a trichothecene mycotoxin which is produced predominantly by members of the Fusarium genus [1]. 15-acetoxy Scirpenol could induce apoptotic cell death in human Jurkat T cells. Mycotoxins of scirpenol belong to the trichothecene family which is mainly produced by the fungal species of the genus Fusarium. Acetoxylated scirpenol has very high toxicities in animals and humans. 15-acetoxy Scirpenol exhibited cytotoxicity at a lower concentration (25 ng/ml). The 50% inhibitory concentration (IC50) values of 15-acetoxy Scirpenol was 16.1 ng/ml [2]. In the Jurkat T cells treated with 50 ng/ml of 15-acetoxyscirpenol (15-MAS), the populations of externalized PS-positive and PI-negative cells were 32.0% [2].
References:
[1] Peraica M, Radic B, Lucic A, et al. Toxic effects of mycotoxins in humans[J]. Bulletin of the World Health Organization, 1999, 77(9): 754-766.
[2] Lee D H, Park T, Kim H W. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins[J]. Biological and Pharmaceutical Bulletin, 2006, 29(4): 648-654.
| Physical Appearance | A powder |
| Storage | Store at -20°C |
| M.Wt | 324.4 |
| Cas No. | 2623-22-5 |
| Formula | C17H24O6 |
| Synonyms | 4-Deacetylanguidin,NSC 267030 |
| Solubility | ≤10mg/ml in methanol;10mg/ml in dichloromethane |
| Chemical Name | 12,13-epoxy-trichothec-9-ene-3α,4β,15-triol, 15-acetate |
| SDF | Download SDF |
| Canonical SMILES | CC1=C[C@]2([H])[C@]([C@]([C@H](O)[C@H]3O)(C)[C@@]4(OC4)[C@]3([H])O2)(COC(C)=O)CC1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
