Luotonin F
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Luotonin F is an alkaloid found in the aerial parts of the Peganum nigellastrum Bunge, a plant which has been long used in traditional Chinese medicine for the treatment of rheumatism, abscesses, and various other inflammatory conditions [1].
Due to their biological and pharmaceutical activities, many synthetic methods have been developed for the synthesis of luotonins. An efficient one-pot synthetic protocol has been proposed for the synthesis of luntonin F from easily available starting materials. Through the rational logical design, multifundamental reactions were assembled in one-pot, such as iodination, Kornblum oxidation, and annulations [2]. The developed approach could efficiently synthesize luntonin F and various analogues. Luotonin F showed promising cytotoxicity against leukemia P-388 cells with an IC50 value of 2.3 μg/ml by stabilizing the DNA topoisomerase I-DNA complex [1].
References:
[1] Liang J L, Cha H C, Jahng Y. Recent advances in the studies on luotonins[J]. Molecules, 2011, 16(6): 4861-4883.
[2] Zhu Y, Fei Z, Liu M, et al. Direct one-pot synthesis of Luotonin F and analogues via rational logical design[J]. Organic letters, 2012, 15(2): 378-381.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 301.3 |
Cas No. | 244616-85-1 |
Formula | C18H11N3O2 |
Solubility | ≤2.5mg/ml in DMSO;2.5mg/ml in dimethyl formamide |
Chemical Name | 2-(3-quinolinylcarbonyl)-4(3H)-quinazolinone |
SDF | Download SDF |
Canonical SMILES | O=C1NC(C(C2=CC(C=CC=C3)=C3N=C2)=O)=NC4=CC=CC=C41 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |