SE 175
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SE 175 is a NO donor.
Nitric oxide (NO) mediates various physiological and pathophysiological processes in the cardiovascular system. Pharmacological compounds releasing NO are useful tools for evaluating the critical role of NO in cardiovascular physiology and therapeutics. These NO donors constitute two broad classes of compounds, those releasing NO and those requiring enzymatic metabolism to generate NO.
In vitro: SE 175 was identified as an organic nitrate donor of the same class as nitroglycerin, which acted as NO-donors following reductive transformation of the nitrate group to nitric oxide. SE 175 and other nitroxyacylated thiosalicylates were developed in an effort to facilitate such reductive process and accelerate the release of NO. SE 175 was found to be stable in buffer or saline solution. In addition, SE 175 was able to stimulate endothelial soluble guanylate cyclase and induce aortic vasorelaxation with an EC50 of 20 μM, which was intermediate in potency between isosorbide dinitrate and nitroglycerine [1].
In vivo: Up to now, there is no animal in vivo data reported.
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Endres, S. ,Hacker, A.,Noack, E., et al. NO-donors, Part 3: Nitrooxyacylated thiosalicylates and salicylates-synthesis and biological activities. European Journal of Medicinal Chemistry 34, 895-901 (1999).
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 347.3 |
Cas No. | 258278-64-7 |
Formula | C16H13NO6S |
Solubility | ≤11mg/ml in ethanol;35mg/ml in DMSO;50mg/ml in dimethyl formamide |
Chemical Name | 2-[[4-[(nitrooxy)methyl]benzoyl]thio]-benzoic acid, methyl ester |
SDF | Download SDF |
Canonical SMILES | COC(=O)c1ccccc1SC(=O)c1ccc(CO[N](=O)O)cc1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |