NSC348884
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
作用于测试的癌细胞系,IC50为1.7-4.0 μM。
NSC348884是一种核磷蛋白抑制剂。
经鉴定,核磷蛋白是一种多功能核仁磷酸蛋白,在人类恶性肿瘤中失调,导致抗凋亡和分化抑制。
体外:经鉴定,NSC348884是推定的核磷蛋白小分子抑制剂,能够破坏寡聚化所需的疏水口袋,NSC348884也可以抑制不同癌细胞系中的细胞增殖并破坏核磷蛋白低聚物形成。此外,用NSC348884治疗几种癌细胞类型可以剂量依赖性地上调p53并且诱导与H2AX磷酸化、聚(ADP-核糖)聚合酶切割以及膜联蛋白V相关的凋亡。此外,NSC348884还可以协同多柔比星对癌细胞活力的细胞毒性[1]。
体内:先前的研究显示,将NSC348884注射到荷瘤小鼠中后,体内灌流和侵入可以被显著抑制。此外,在4小时的短暂治疗中,在治疗的肿瘤中通过组织学观察到的总细胞死亡没有显著差异,表明所观察到的抑制是迁移特异性的[2]。
临床试验:到目前为止,NSC348884仍处于临床前研究阶段。
参考文献:
[1] Qi W,Shakalya K,Stejskal A,Goldman A,Beeck S,Cooke L,Mahadevan D. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. Oncogene.2008 Jul 10;27(30):4210-20.
[2] Patsialou A,Wang Y,Lin J,Whitney K,Goswami S,Kenny PA,Condeelis JS. Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast Cancer Res.2012 Oct 31;14(5):R139.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 636.79 |
Cas No. | 81624-55-7 |
Formula | C38H40N10 |
Solubility | ≥63.7 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
Chemical Name | N1,N1,N2,N2-tetrakis((6-methyl-1H-benzo[d]imidazol-2-yl)methyl)ethane-1,2-diamine |
SDF | Download SDF |
Canonical SMILES | CC1=CC=C2N=C(CN(CC3=NC4=CC=C(C)C=C4N3)CCN(CC5=NC6=CC=C(C)C=C6N5)CC7=NC8=CC=C(C)C=C8N7)NC2=C1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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