Zaragozic Acid A
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
作用于大鼠肝脏角鲨烯合酶的Ki值为78 pM。
通过筛选天然产物来源以发现角鲨烯合酶的抑制剂，两个相互独立的研究组发现了zaragozic acids (ZAs)，一种含有新型4,6,7-三羟基-2,8-二氧代二环[3.2.1]辛烷-3,4,5-三羧酸核的真菌代谢物家族。
体外：Zaragozic acid A及其两种类似物Zaragozic acid B和Zaragozic acid C分别从未鉴定的无菌真菌培养物、Spororniella intermedia和Leptodontium elatius发现。据报道，Zaragozic acid A、B和C是三种强效的大鼠肝角鲨烯合酶竞争性抑制剂，Ki值分别为78pM、29 pM和45 pM。此外，Zaragozic acid A、B和C也可以抑制Hep G2细胞中的胆固醇合成[1]。
体内：在小鼠模型中发现，Zaragozic acid A是急性肝胆固醇合成的一种抑制剂（50％抑制剂量为200 μg/ kg）。角鲨烯合酶的体内抑制伴随着标记物从[3H]甲羟戊酸向二磷酸法呢酯、法呢醇以及有机酸的积累。总之，这些数据表明，zaragozic acids是一类具有高胆固醇血症治疗潜力的新型治疗剂[1]。
临床试验：到目前为止，zaragozic acid A仍处于临床前研究阶段。
参考文献：
[1] Bergstrom JD,Kurtz MM,Rew DJ,Amend AM,Karkas JD,Bostedor RG,Bansal VS,Dufresne C,VanMiddlesworth FL,Hensens OD, et al. Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. Proc Natl Acad Sci U S A.1993 Jan 1;90(1):80-4.
| Physical Appearance | A white to light tan solid |
| Storage | Store at -20°C |
| M.Wt | 690.73 |
| Cas No. | 142561-96-4 |
| Formula | C35H46O14 |
| Solubility | Soluble in DMSO |
| Chemical Name | (1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-acetoxy-5-methyl-3-methylene-6-phenylhexyl)-6-(((4S,6S,E)-4,6-dimethyloct-2-enoyl)oxy)-4,7-dihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | O[C@@H]1[C@H]([C@@]2([C@](C(O)=O)([C@H](O[C@@]1(CCC([C@H]([C@@H](CC3=CC=CC=C3)C)OC(C)=O)=C)O2)C(O)=O)O)C(O)=O)OC(/C=C/[C@H](C[C@H](CC)C)C)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
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化学结构
