Dolastatin 10 trifluoroacetate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Dolastatin 10 trifluoroacetate是一种抗肿瘤剂[1]。
Dolastatin 10 trifluoroacetate是从海洋动物中分离的，是一种有效的抗有丝分裂多肽，被开发作为潜在的抗肿瘤剂。Dolastatin 10被发现具有抑制微管蛋白聚合的活性，IC50值为1.2 μM。此外，它以非竞争性的方式有效地抑制长春新碱与微管蛋白的结合，Ki值为1.4 μM。Dolastatin 10还可以一定程度上加强秋水仙素与微管蛋白的结合。此外，Dolastatin 10对微管蛋白依赖性的GTP结合具有抑制活性[1]。
在细胞实验中，Dolastatin 10对某些人白血病、淋巴瘤和实体瘤细胞系具有一定的活性，如OVCAR-3和NSCLC，IC50值范围从0.1 nM至10 nM。目前已进入临床试验[2]。
参考文献：
[1] Bai R L, Pettit G R, Hamel E. Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. Journal of Biological Chemistry, 1990, 265(28): 17141-17149.
[2] Schwartsmann G. Marine organisms and other novel natural sources of new cancer drugs. Annals of Oncology, 2000, 11(suppl 3): 235-243.
| Storage | Store at -20°C |
| M.Wt | 899.11 |
| Cas No. | N/A |
| Formula | C44H69F3N6O8S |
| Solubility | Soluble in DMSO |
| Chemical Name | 2,2,2-trifluoroacetic acid compound with (S,Z)-2-(dimethylamino)-N-((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R,Z)-3-hydroxy-1-methoxy-2-methyl-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)imino)propyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino) |
| SDF | Download SDF |
| Canonical SMILES | CC[C@]([C@@](N(C([C@](/N=C(O)/[C@](N(C)C)([H])C(C)C)([H])C(C)C)=O)C)([H])[C@@](OC)([H])CC(N1CCC[C@@]1([H])[C@@](OC)([H])[C@@](/C(O)=N/[C@@](C2=NC=CS2)([H])CC3=CC=CC=C3)([H])C)=O)([H])C.FC(F)(C(O)=O)F |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
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