MnTBAP Chloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
超氧化物(O2-)是近端线粒体活性氧,参与病理过程以及氧化还原信号传导.因而,急需研发用于控制O2-的线粒体靶向药物.MnTBAP是一种新型的\稳定的和细胞渗透性的超氧化物歧化酶模拟物.
体外:由于其超氧化物歧化酶模拟物特性,50 microM MnTBAP呈剂量依赖性地缓解暴露于各种浓度百草枯(4小时)而产生的伤害.MnTBAP还呈剂量依赖性地保护内皮细胞免受百草枯影响.由于其锌形式和CuZnSOD均不能保护细胞免受百草枯诱导的损伤,MnTBAP可能是基于胞内清除超氧化物而发挥保护作用[1].
体内:在所有时间点,MnTBAP局部给药均呈剂量依赖性地显著减少角叉菜胶诱导的足跖肿胀,上述作用与其超氧化物歧化酶模拟物特性相关.此外,MnTBAP也呈剂量依赖性地显著减少足跖髓过氧化物酶活性并保护组织免受损伤.免疫组织化学分析结果表明,在经角叉菜胶处理的大鼠足跖中,硝基酪氨酸显示出阳性染色[2].
临床试验:到目前为止,MnTBAP还处于临床前开发阶段.
参考文献：
[1] Day BJ, Shawen S, Liochev SI, Crapo JD. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro. J Pharmacol Exp Ther. 1995 Dec;275(3):1227-32.
[2] Cuzzocrea S, Costantino G, Mazzon E, Zingarelli B, De Sarro A, Caputi AP. Protective effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in paw oedema induced by carrageenan in the rat. Biochem Pharmacol. 1999 Jul 1;58(1):171-6.
| Storage | Store at 4°C |
| M.Wt | 879.15 |
| Cas No. | 55266-18-7 |
| Formula | C48H28ClMnN4O8 |
| Solubility | ≥25.4 mg/mL in DMSO |
| SDF | Download SDF |
| Canonical SMILES | O=C([O-])C1=CC=C(/C(C(C=C/2)=NC2=C3C4=CC=C(C(O)=O)C=C4)=C([N-]/5)/C=CC5=C(C(N6)=CC=C6/C(C7=CC=C(C(O)=O)C=C7)=C8C=CC/3=N\8)\C9=CC=C(C([O-])=O)C=C9)C=C1.Cl.[Mn+3] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
