Carmustine
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an antitumor chemotherapeutic agent[1].
In rat glial tumor cytosol and intact cells, carmustine (8, 80, and 800 µM) reduces N-acetyltransferase activities for 2-aminofluorene and p-aminobenzoic acid. In rat glioma cells, carmustine reduces the formation of DNA-AF adducts[1].
Intraperitoneal administration of carmustine 25 mg/kg in rat, which increases liver-to-weight ratio, significantly reduces bile flow, and decreases GSSG and GSH/GSSG values, and mild fibrous edema and monocyte infiltration in the liver of rats[2].
References:
[1].Hung C F. Effects of carmustine and lomustine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in rat glial tumor cells. Neurochem Res, 2000, 25(6): 845-51.
[2].Demir A, et al. The effect of trimetazidine on intrahepatic cholestasis caused by carmustine in rats. Hepatol Res, 2001, 20(1): 133-143.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 214.05 |
| Cas No. | 154-93-8 |
| Formula | C5H9Cl2N3O2 |
| Solubility | insoluble in H2O; ≥21.51 mg/mL in DMSO; ≥27.15 mg/mL in EtOH |
| Chemical Name | (Z)-N,N'-bis(2-chloroethyl)-N-nitrosocarbamimidic acid |
| SDF | Download SDF |
| Canonical SMILES | ClCC/N=C(O)/N(N=O)CCCl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
