Rifapentine
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
MIC:0.015 - 0.06 mg/ml.
肺结核是一种常见的由多种分枝杆菌,主要是结核分枝杆菌引起的传染病.肺结核主要感染肺,但也可影响身体的其他部分.Rifapentine是一种用于治疗肺结核的抗生素药物.
在体外:利福平和rifapentine对人类单核细胞衍生的多核细胞中结核杆菌的效果已被测定.Rifapentine对胞内细菌的MIC和MBC值比利福平低2到4倍.对胞外细菌,差别并不明显[1].
在体内:一周一次使用与600-mg剂量给药后获得血液浓度相等的rifapentine,在第一周细菌数量明显下降,这一下降达到的最低水平维持了四周.这种rifapentine的持续效果可能与比利福平高四到五倍的胞内积累有关[1].
临床试验:Rifapentine可一周两次给药用于肺结核加强期治疗,而后一周一次用于持续期治疗.其在批准剂量600 mg的效果可能比利福平略低.更大剂量的rifapentine能否达到同等或更好效果仍待研究[2].
参考文献：
[1] Mor N, Simon B, Mezo N, Heifets L. Comparison of activities of rifapentine and rifampin against Mycobacterium tuberculosis residing in human macrophages. Antimicrob Agents Chemother. 1995 Sep;39(9):2073-7.
[2] Temple ME, Nahata MC. Rifapentine: its role in the treatment of tuberculosis. Ann Pharmacother. 1999 Nov;33(11):1203-10.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 877.03 |
| Cas No. | 61379-65-5 |
| Formula | C47H64N4O12 |
| Solubility | ≥30.25 mg/mL in DMSO; insoluble in H2O; ≥2.87 mg/mL in EtOH with ultrasonic |
| SDF | Download SDF |
| Canonical SMILES | O[C@H]([C@H](C)[C@@H](O)[C@@H](C)/C=C/C=C1/C)[C@@H](C)[C@@](OC(C)=O)([H])[C@H](C)[C@@H](OC)/C=C/O[C@@]2(C)OC3=C(C2=O)C(C(O)=C4/C=N/N5CCN(C6CCCC6)CC5)=C(C(O)=C3C)C(O)=C4NC1=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
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