Escitalopram
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Escitalopram(Lexapro,Cipralex)是选择性5-羟色胺(5-HT)再摄取抑制剂(SSRI),对[3H]-5-HT摄取的Ki值为6.6 nM[1].
Escitalopram是citalopram 的S-(+)-对映体.在表达人5-羟色胺转运体(5-HTT)的COS-1细胞中,Escitalopram抑制[3H]-5-HT摄取以及[125I]-RTI-55结合,其Ki值分别为6.6 ± 1.4 nM和3.9 ± 2.2 nM.据报道,Escitalopram体外抑制3H标记的单胺类物质在大鼠脑突触体累积,对[3H]-5-HT\[3H]-I-NA和[3H]-DA的IC50值分别为2.1 ± 0.75 nM\2500 ± 202 nM和40000 ± 15500 nM.此外,Escitalopram体外作用于大鼠组胺H1受体和大鼠σ1位点,Ki值分别为1500 ± 780 nM和100 ± 71 nM[1].
参考文献：
[1] Sánchez C1, Bergqvist PB, Brennum LT, Gupta S, Hogg S, Larsen A, Wiborg O. Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. Psychopharmacology (Berl). 2003 Jun;167(4):353-62. Epub 2003 Apr 26.
| Storage | Store at -20°C |
| M.Wt | 324.39 |
| Cas No. | 128196-01-0 |
| Formula | C20H21FN2O |
| Solubility | Soluble in DMSO |
| Chemical Name | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile |
| SDF | Download SDF |
| Canonical SMILES | CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
