PA-824
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
PA-824是一种双环的硝基咪唑，是一种抗肺结核（TB）制剂，在体外具有有效的抗结核分枝杆菌活性，最小抑制浓度（MIC）从0.015 μg/ml到0.25 μg/ml不等，并可有效拮抗多种对常见抗TB制剂耐受的菌株，使其成功用于抗TB治疗[1]。
PA-824在缺氧或长时间培养条件下以剂量依赖的方式对复制杆菌和非复制杆菌展示出杀菌活性，这通过两种可能的途径，包括PA-824诱导的ketomycolate合成抑制和酶促硝基还原过程中PA-824介导的一氧化氮释放[1]。
参考文献：
[1] Ahmad Z, Peloquin CA, Singh RP, Derendorf H, Tyagi S, Ginsberg A, Grosset JH, Nuermberger EL. PA-824 exhibits time-dependent activity in a murine model of tuberculosis. Antimicrob Agents Chemother. 2011 Jan;55(1):239-45. doi: 10.1128/AAC.00849-10. Epub 2010 Oct 11.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 359.26 |
| Cas No. | 187235-37-6 |
| Formula | C14H12F3N3O5 |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥17.85 mg/mL in DMSO |
| Chemical Name | (6S)-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine |
| SDF | Download SDF |
| Canonical SMILES | C1C(COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | PA-824是一种抗肺结核药，MIC值小于2.8 μM。 | |||||
| 靶点 | tuberculosis | |||||
| IC50 | <2.8 μM | |||||
质量控制和MSDS
- 批次:
化学结构
