D-64131
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
D-64131是微管蛋白聚合抑制剂，IC50值为0.53 μM[1]。
D-64131以剂量依赖的方式抑制牛脑微管蛋白的聚合以及[3H]秋水仙碱与生物素化的αβ微管蛋白的结合。使用D-64131处理后，许多癌细胞的微管结构异常，例如破碎的有丝分裂纺锤体以及多个纺锤极。D-64131处理的许多细胞中出现核起泡和异常核结构，这是凋亡细胞的典型特征。在人无色素恶性黑色素瘤MEXF989异种移植的裸鼠体内，D-64131显示出良好的耐受性和较高的活性。D-64131显著抑制治疗期间的肿瘤生长[1]。
参考文献：
1. Beckers T, Reissmann T, Schmidt M et al. 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Res. 2002 Jun 1;62(11):3113-9.
| Physical Appearance | Yellow crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 251.28 |
| Cas No. | 74588-78-6 |
| Formula | C16H13NO2 |
| Synonyms | D 64131;D64131 |
| Solubility | Soluble in DMSO |
| Chemical Name | (5-methoxy-1H-indol-2-yl)(phenyl)methanone |
| SDF | Download SDF |
| Canonical SMILES | COC1=CC2=C(C=C1)NC(=C2)C(=O)C3=CC=CC=C3 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
