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Pro-Adrenomedullin (153-185), human

现货
Catalog No.
A1101
血管舒张药
组合的产品项目
规格价格库存 数量
1mg
¥ 1,500.00
Ship with 10-15 days
5mg
¥ 4,500.00
Ship with 10-15 days
10mg
¥ 7,500.00
Ship with 10-15 days
25mg
¥ 10,500.00
Ship with 10-15 days

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Background

Pro-Adrenomedullin(153-185),human, (C143H224N42O43), a peptide with the sequence H2N-SLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL-OH, MW= 3219.6. Adrenomedullin (AM) is a ubiquitously expressed peptide initially isolated from phaechromyctoma in 1993(1). AM was initially identified as a vasodilator, some have cited this as the most potent endogenous vasodilatory peptide found in the body (2). Differences in opinion regarding the ability of AM to relax vascular tone arises from the differences in the model system used (3). Other effects of AM include increasing the tolerance of cells to oxidative stress and hypoxic injury and angiogenesis. AM is seen as a positive influence in diseases such as hypertension, myocardial infarction, chronic obstructive pulmonary disease and other cardiovascular diseases, whereas it can be seen as a negative factor in potentiating the potential of cancerous cells to extend their blood supply and cause cell proliferation.

A1101_1

Figure1  structure of Adrenomedullin

A1101_2

Figuresignal pathway of adrenomedullin

Ref:

1.Kitamura K, Kato J, Kawamoto M, Tanaka M, Chino N, Kangawa K, et al. The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma. Biochem Biophys Res Commun 1998;244:551-555

2. Cockcroft et al., Br J Clin Pharmacol. 1997 Jul;44(1):57-60.

3. Hamid SA, Baxter GF, Pharmacol Ther. Feb;105(2):95-112.2005.

 

Chemical Properties

StorageStore at -20°C
M.Wt3219.6
FormulaC143H224N42O43
SynonymsH2N-Ser-Leu-Pro-Glu-Ala-Gly-Pro-Gly-Arg-Thr-Leu-Val-Ser-Ser-Lys-Pro-Gln-Ala-His-Gly-Ala-Pro-Ala-Pro-Pro-Ser-Gly-Ser-Ala-Pro-His-Phe-Leu-OH
SDFDownload SDF
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

质量控制

质量控制和MSDS

批次:

化学结构

Pro-Adrenomedullin (153-185), human