Imperatorin

Imperatorin是一种抗癌药，具有多个靶点，可诱导细胞凋亡，如提高p53表达[1]，诱导Mcl-1降解[2]，激活caspase-3、caspase-8和caspase-9活性[3]。

在人类癌细胞系（SNU 449肝癌和HCT-15结肠癌）中，imperatorin处理可调控凋亡相关蛋白表达，以剂量依赖的方式促进细胞凋亡[4]。在人类胚肾细胞中，imperatorin处理可显著减弱H2O2诱导的ROS生成[5]。在人类肝癌HepG2细胞中，imperatorin处理可以时间和剂量依赖的方式抑制细胞增殖[3]。在人类肺癌H23细胞中，imperatorin可在亚毒性浓度下提高p53表达，诱导细胞凋亡[1]。

在携带HepG2细胞的裸鼠模型中，imperatorin处理可以剂量依赖地方式显著抑制肿瘤生长[3]。

据报道，在神经元NG-108-15细胞中，imperatorin可抑制电压门控的K+通道和ATP敏感的K+通道[6]。

参考文献：
[1].  Choochuay, K., et al., Imperatorin sensitizes anoikis and inhibits anchorage-independent growth of lung cancer cells. J Nat Med, 2013. 67(3): p. 599-606.
[2].  Li, X., et al., Imperatorin induces Mcl-1 degradation to cooperatively trigger Bax translocation and Bak activation to suppress drug-resistant human hepatoma. Cancer Lett, 2014. 348(1-2): p. 146-55.
[3].  Luo, K.W., et al., Anticancer effects of imperatorin isolated from Angelica dahurica: induction of apoptosis in HepG2 cells through both death-receptor- and mitochondria-mediated pathways. Chemotherapy, 2011. 57(6): p. 449-59.
[4].  Rahman, A., et al., Growth inhibition of various human cancer cell lines by imperatorin and limonin from poncirus trifoliata rafin. Seeds. Anticancer Agents Med Chem, 2015. 15(2): p. 236-41.
[5].  Cao, Y., et al., Antioxidant effect of imperatorin from Angelica dahurica in hypertension via inhibiting NADPH oxidase activation and MAPK pathway. J Am Soc Hypertens, 2014. 8(8): p. 527-36.
[6].  Wang, Y.W., et al., Inhibitory effects of imperatorin on voltage-gated K(+) channels and ATP-sensitive K(+) channels. Pharmacol Rep, 2015. 67(1): p. 134-9.