Ursolic acid
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Ursolic Acid对P3HR1细胞和骨髓性白血病K562细胞的IC50值分别为2.5 μg/mL和17.79 μg/mL。
Ursolic Acid，一种乌索烷型五环三萜酸，属于环状三萜类化合物，可用于癌症预防与治疗。癌症发展的各个阶段与多种炎症信号级联反应相关，包括核因子-κB以及环氧合酶-2。
体外：Ursolic Acid抑制多种肿瘤细胞增殖，诱导细胞凋亡，抑制肿瘤转移、肿瘤生长以及血管生成。此外，Ursolic acid通过抑制IkBa激酶和p65/RelA磷酸化，从而抑制致癌剂诱导的NF-κB激活[1]。
体内：在各种癌症动物模型中，Ursolic Acid在体内抑制肿瘤生长。在裸鼠中，给予Ursolic Acid，持续6周，能抑制DU145细胞生长，同时对体重无显著影响。在转基因小鼠前列腺癌模型中，Ursolic Acid具有预防作用[1]。
临床试验：63例受试者接受单剂量Ursolic Acid脂质体。临床试验结果表明，Ursolic Acid脂质体具有较轻的毒性，其MTD值为98 mg/m2。剂量限制性毒性主要包括腹泻与肝毒性。此外，Ursolic Acid脂质体制剂具有线性药物动力学特征[1]。
参考文献：
[1] Shanmugam MK, Dai X, Kumar AP, Tan BK, Sethi G, Bishayee A. Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies. Biochem Pharmacol. 2013 Jun 1;85(11):1579-87.
| Storage | Store at -20°C |
| M.Wt | 456.68 |
| Cas No. | 77-52-1 |
| Formula | C30H48O3 |
| Synonyms | 3-Hydroxy-12-ursen-28-oic acid |
| Solubility | ≥21.55 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C)C)C(=O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Quality Control & MSDS
- View current batch:
化学结构
