type I hair keratin fragment [Homo sapiens]/[Ovis aries]/[Rattus norvegicus]
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
人I型发角蛋白亚家族包括9个成员，可以分成三类，A类包含hHa1、hHa3-I、hHa3-II和hHa4，B类包含hHa7和hHa8，均含有结构相关的发角蛋白，而C类成员包含有hHa2、hHa5和hHa6，结构上与发角蛋白无关1。
角蛋白分为I型和II型，I型为酸性，II型为碱性至中性，等摩尔量的I型和II型角蛋白相互作用，形成上皮细胞的10 nm的中间纤维细胞骨架网络2,3,4。
对解析得到的一维结构的人发角蛋白进行western blots分析，发角蛋白的抗体具有高度特异性，只识别单个蛋白质条带。hHa2的抗体是例外，除了有一个明显的hHa2蛋白带，也有一个稍大的弱条带1。LEF-1共有序列是位于人I型发角蛋白家族成员的近端启动子区的高度保守位置，但是在hHa7基因的整个启动子中，都缺乏这个共有序列5。
Figure1. Structure of hair keratin
参考文献：
1. L. Langbein, M. A. Rogers et al. The Catalog of Human Hair Keratins. The journal of biological chemistry. 274: 19874–19884, 1999
2.Steinert, P. M., and Roop, D. R. (1988) Annu. Rev. Biochem. 57, 593–625.
3.Fuchs, E., and Weber, K. (1994) Annu. Rev. Biochem. 63, 345–382.
4.Mischke, D. (1998) in Intermediate Filaments: Subcellular Biochemistry (Herrmann, H., and Harris, J. R., eds) Vol. 31, pp. 71–95, Plenum Press, New York.
5.Rogers, M. A., Winter, H., Wolf, C., Jacobs, M., and Schweizer, J. (1998)J. Biol. Chem. 273, 26683–26691.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 1064.19 |
| Formula | C47H77N13O15 |
| Synonyms | H2N-Leu-Asn-Asp-Arg-Leu-Ala-Ser-Tyr-Leu-OH |
| Solubility | ≥106.4 mg/mL in DMSO; insoluble in EtOH; ≥49 mg/mL in H2O |
| SDF | Download SDF |
| Canonical SMILES | NC(CC(C)C)C(NC(CC(N)=O)C(NC(CC(O)=O)C(NC(CCCNC(N)=N)C(NC(CC(C)C)C(NC(C)C(NC(CO)C(NC(CC1=CC=C(O)C=C1)C(NC(CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
![type I hair keratin fragment [Homo sapiens]/[Ovis aries]/[Rattus norvegicus]](http://www.apexbt.com//media/diy/images/struct/A1095.png)