Captopril
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Captopril是一种血管紧张素I转化酶（ACE）的抑制剂，IC50值为6 nM[1]。
Captopril是一种具有抗高血压功能的老药，常用于控制血压。Captopril在所有的物种研究中都表现为ACE抑制剂。正常人类和清醒的血压正常的兔子使用captopril可抑制静脉注射血管紧张素I诱导的压力响应，但对血管紧张素II引发的则无功效。对于顽固性高血压病人，Captopril被证明是一种与降压药疗法结合使用的有效选择[2]。
Captopril也被发现具有抗癌活性。该物质能在LNM35人类肺细胞异种移植物的无胸腺小鼠中显著减缓肿瘤生长而无毒性。Captopril被证明可通过诱发细胞凋亡而影响细胞生长[3]。
参考文献：
[1] FitzGerald RJ, Meisel H. Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme. Br J Nutr. 2000 Nov;84
[2] Bravo EL, Tarazi RC. Converting enzyme inhibition with an orally active compound in hypertensive man. Hypertension. 1979 Jan-Feb;1(1):39-46.
[3] Attoub S, Gaben AM, Al-Salam S, Al Sultan MA, John A, Nicholls MG, Mester J, Petroianu G. Captopril as a potential inhibitor of lung tumor growth and metastasis. Ann N Y Acad Sci. 2008 Sep;1138:65-72.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 217.29 |
| Cas No. | 62571-86-2 |
| Formula | C9H15NO3S |
| Solubility | ≥21.7 mg/mL in DMSO; ≥105.2 mg/mL in EtOH with ultrasonic; ≥48.6 mg/mL in H2O with ultrasonic |
| Chemical Name | 1-(3-mercapto-2-methylpropanoyl)pyrrolidine-2-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | OC(C1CCCN1C(C(CS)C)=O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
