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c-Myc tag Peptide

现货
Catalog No.
A6003
合成的多肽标签
组合的产品项目
规格价格库存 数量
10mM (in 1mL DMSO)
¥ 2,300.00
现货
5mg
¥ 600.00
现货
25mg
¥ 2,700.00
现货

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Background

c-Myc Peptide is a useful displacement of c-Myc-tagged fusion proteins bound to anti-c-Myc antibodies in immunoassays. The successful inhibition of antibody binding by c-Myc peptide demonstrates binding is specific. c-Myc peptide participates in regulation of growth-related gene transcription.

The c-Myc Peptide is a synthetic peptide with an amino acid sequence that corresponds to the amino acids 410-419 of the C-terminal of human c-myc. Myc (c-Myc) is a regulator gene that codes for a transcription factor. c-Myc activation results in numerous biological effects. The first to be discovered was its capability to drive cell proliferation (upregulates cyclins, downregulates p21), but it also plays a very important role in regulating cell growth (upregulates ribosomal RNA and proteins), apoptosis (downregulates Bcl-2), differentiation and stem cell self-renewal. C-Myc is a very strong proto-oncogene and it is very often found to be upregulated in many types of cancers. c-Myc overexpression stimulates gene amplification, [1] presumably through DNA over-replication.

References:
1. Denis N, Kitzis A, Kruh J, Dautry F, Corcos D (August 1991). "Stimulation of methotrexate resistance and dihydrofolate reductase gene amplification by c-myc". Oncogene 6 (8): 1453–7.

Chemical Properties

StorageDesiccate at -20°C
M.Wt1203.3
FormulaC51H86N12O21
SynonymsH-Glu-Gln-Lys-Leu-Ile-Ser-Glu-Glu-Asp-Leu-OH
Solubility≥60.165mg/mL in DMSO, <2.07 mg/mL in EtOH, ≥15.7 mg/mL in H2O with ultrasonic
Chemical Namec-Myc Peptide
SDFDownload SDF
Canonical SMILESN[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](C)CC)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

生物活性

Description c-Myc tag Peptide(c-Myc标签肽)是一种合成的多肽,对应于人c-myc蛋白羧基端氨基酸序列(410-419)。
靶点 anti-c-Myc antibody          
IC50            

质量控制

化学结构

c-Myc tag Peptide

相关生物数据

c-Myc tag Peptide