BYK 204165
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BYK204165是一个有效的和选择性的聚(ADP-核糖) 聚合酶 (PARP)-1的抑制剂，对PARP-2和PARP-1的pIC50值分别为5.38和7.35[1]。
PARP1是DNA链断裂激活的核酶，参与调节各种细胞过程，如DNA修复、细胞凋亡、器官功能障碍或坏死[1]。
BYK204165（PARP抑制剂XIV）强效和选择性抑制PARP1，是一种细胞渗透性异喹啉化合物。BYK204165的效力与大多数当前标准的PARP-1抑制剂相似或更高，比PJ34稍低，对PARP-1的选择性比PARP-2高100倍[1]。
BYK的水溶性较差，所以BYK204165未用于体内研究。
参考文献：
[1]. Eltze T, Boer R, Wagner T, et al. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol Pharmacol, 2008, 74(6): 1587-98.
| Physical Appearance | Yellow solid |
| Storage | Desiccate at 4°C |
| M.Wt | 252.27 |
| Cas No. | 1104546-89-5 |
| Formula | C15H12N2O2 |
| Solubility | <25.23mg/ml in DMSO |
| Chemical Name | (4E)-4-[(1-methylpyrrol-2-yl)methylidene]isoquinoline-1,3-dione |
| SDF | Download SDF |
| Canonical SMILES | CN1C=CC=C1C=C2C3=CC=CC=C3C(=O)NC2=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
