BWX 46
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50:Y5受体的IC50为0.5 nM.
神经肽Y(NPY)的活性至少由六种G蛋白偶联受体介导,即Y1\Y2\Y3\Y4\Y5和Y6.受体选择性配体和受体敲除小鼠的研究表明,NPY对喂养的效应是通过Y1和Y5这两种受体介导的.BWX 46是Y5受体的选择性激动剂.
体外实验:BWX 46选择性地结合Y5受体,抑制Y5细胞cAMP的合成,效力与NPY相当.此外,BWX 46(10 μM)对Y1\Y2和Y4细胞的cAMP合成无显著影响.因此,BWX 46是迄今为止报道的分子量最低的Y5的选择性激动剂[1].
在体实验:老鼠下丘脑内注射的30和40 μg BWX 46以渐进的方式刺激食物的摄入,注射后8小时达到最高水平.这种反应类似于其他Y5受体的选择性激动剂,但与NPY在1小时内更快捷促进食欲的刺激不同[1].
临床试验:截至目前,BWX 46仍处于临床前开发阶段.
参考文献：
[1] Ambikaipakan Balasubramaniam, Sulaiman Sheriff, Weixu Zhai, William T. Chance. Bis(31/31’){[Cys31, Nva34]NPY(27–36)-NH2}: a neuropeptide Y (NPY) Y5 receptor selective agonist with a latent stimulatory effect on food intake in rats. Peptides 23 (2002) 1485–1490
| Physical Appearance | A solid |
| Storage | Desiccate at -20°C |
| M.Wt | 2597.07 |
| Cas No. | 172997-92-1 |
| Formula | C116H186N36O28S2 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥260.4 mg/mL in DMSO with ultrasonic |
| Chemical Name | (2S,5S,8S,11S,14R,17S,20S,Z)-N'1-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-20-((2S,3S)-2-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-14-((5R,8S,11S,14S,17S)-22-amino-5-((S)-2-((S)-4-amino-2-((2S,3S)-2-((S)-2-amino-3-(4-hydro |
| SDF | Download SDF |
| Canonical SMILES | CCC[C@@](NC([C@](NC([C@](NC([C@](NC([C@](NC([C@](NC([C@](NC([C@](N)([H])CC1=CC=C(O)C=C1)=O)([H])[C@@](CC)([H])C)=O)([H])CC(O)=N)=O)([H])CC(C)C)=O)([H])CSSC[C@@](NC([C@](NC([C@](NC([C@](NC([C@](N)([H])CC2=CC=C(O)C=C2)=O)([H])[C@@](CC)([H])C)=O)([H])CC(N)=O |
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质量控制和MSDS
- 批次:
化学结构
