BW 723C86 hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BW 723C86 hydrochloride是一种选择性的5-HT2B受体激动剂[1].
5-HT2B受体是一种内源性神经递质血清素(5-HT)的G蛋白偶联受体,并在血小板形状改变\血管收缩和对触觉刺激的神经元敏化中起重要作用.
BW 723C86 hydrochloride是一种选择性的5-HT2B受体激动剂.BW723C86可逆地增加心脏迷走神经元(CVNs)中微小兴奋性突触后电流(mEPSCs)的振幅和频率,这被P2受体拮抗剂PADS阻断.BW723C86通过P2X受体促进到CVNs的兴奋性嘌呤神经传递[2].
在大鼠社会交往试验中,BW 723C86(3或10 mg / kg)增加总交互作用并诱导5-HT2B受体介导的抗焦虑样作用[1].在大鼠Vogel冲突试验中,BW 723C86(10或30 mg / kg)增加惩罚数量,这由5-HT2B受体介导并与其抗焦虑样特性一致[3].在神经性疼痛大鼠模型中,BW723C86剂量依赖性地显著抑制机械性异常疼痛和冷异常性疼痛[4].
参考文献：
[1]. Kennett GA, Bright F, Trail B, et al. Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety. Br J Pharmacol, 1996, 117(7): 1443-1448.
[2]. Dergacheva O, Wang X, Kamendi H, et al. 5HT2 receptor activation facilitates P2X receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Neuropharmacology, 2008, 54(7): 1095-1102.
[3]. Kennett GA, Trail B, Bright F. Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology, 1998, 37(12): 1603-1610.
[4]. Urtikova N, Berson N, Van Steenwinckel J, et al. Antinociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain. Pain, 2012, 153(6): 1320-1331.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 322.85 |
| Cas No. | 160521-72-2 |
| Formula | C16H18N2OS·HCl |
| Solubility | Soluble in DMSO |
| Chemical Name | (R)-1-(5-(thiophen-2-ylmethoxy)-1H-indol-3-yl)propan-2-amine hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | N[C@H](C)CC(C1=C2)=CNC1=CC=C2OCC3=CC=CS3.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
