BW 373U86
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Ki值:对delta\mu\epsilon和kappa受体分别为1.8\15\85和34 nM.
阿片受体是异质的,至少有四种类型,已知存在的有mu\delta\kappa和epsilon.目前,所有临床使用的阿片剂通过mu受体发挥作用,诱导镇痛;但是,这些物质也引起了有害的副作用,如呼吸抑制\依赖症\便秘和肌肉强直.BW 373U86是一种新型有效的非肽类delta阿片受体选择性激动剂.
体外实验:在受体结合试验中,BW 373U86是有效的delta受体的选择性配体,对delta\mu\epsilon和kappa受体结合位点的Ki值分别为1.8 ± 0.4\15 ± 3\85 ± 4和34 ± 3 nM.BW 373U86可抑制电击诱发的小鼠输精管肌肉收缩,ED50值为0.2 ± 0.06 nM[1].
体内实验:大鼠皮下注射0.2到2 mg/kg的BW 373U86可抑制听觉惊吓反射,这一抑制可被naltnndole阻断.在大鼠中,BW 373U86在近似剂量下也可导致剂量依赖的自发运动活性上升.这一效果可被naltnndole抑制[3].
临床试验:迄今为止,BW 373U86仍处于临床前开发阶段.
参考文献:
[1] Chang KJ, Rigdon GC, Howard JL, McNutt RW. A novel, potent and selective nonpeptidic delta opioid receptor agonist BW 373U86. J Pharmacol Exp Ther. 1993 Nov;267(2):852-7.
Physical Appearance | Beige solid |
Storage | Store at -20°C |
M.Wt | 435.61 |
Cas No. | 155836-50-3 |
Formula | C27H37N3O2 |
Solubility | <43.56mg/ml in 1eq. HCl |
Chemical Name | 4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-hydroxyphenyl)methyl)-N,N-diethylbenzamide |
SDF | Download SDF |
Canonical SMILES | OC1=CC([C@@H](C2=CC=C(C(N(CC)CC)=O)C=C2)N3[C@@H](C)CN(CC=C)[C@H](C)C3)=CC=C1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |