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Butenoyl PAF

 
Catalog No.
C5385
PAF受体激动剂
组合的产品项目
规格价格库存 数量
1mg (solution)
¥ 1,516.00
Ship with 10-15 days
5mg (solution)
¥ 5,254.00
Ship with 10-15 days
10mg (solution)
¥ 9,262.00
Ship with 10-15 days
50mg (solution)
¥ 37,537.00
Ship with 10-15 days

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A

背景

Butenoyl PAF is a PAF receptor agonist [1].

Platelet activating factor (PAF), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages. PAF play important roles in a variety of pathophysiological states including acute allergy, inflammation, asthma, gastrointestinal ulceration, and toxic shock [1][2].

Butanoyl-PAF and Butenoyl PAF are both products of the oxidative decomposition of 2-arachidonoyl phospholipids. Although Butenoyl PAF is 10-fold less potent than PAF as a PAF receptor agonist and ligand, it is 100-fold more abundant in oxidized LDL than PAF. Therefore, oxidation products of LDL phospholipids were physiologically relevant bioactive PAF-like molecules [1].

References:
[1].  Marathe GK, Davies SS, Harrison KA, et al. Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines. J Biol Chem. 1999 Oct 1;274(40):28395-404.
[2].  Davies SS, Pontsler AV, Marathe GK, et al. Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists. J Biol Chem. 2001 May 11;276(19):16015-23.

化学属性

Physical AppearanceA solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
StorageStore at -20°C
M.Wt549.7
Cas No.474944-25-7
FormulaC28H56NO7P
Solubility≤0.5mg/ml in DMSO;10mg/ml in dimethyl formamide
Chemical Name1-O-hexadecyl-2-O-(2E-butenoyl)-sn-glyceryl-3-phosphocholine
SDFDownload SDF
Canonical SMILESO=C(/C=C/C)O[C@@H](COP([O-])(OCC[N+](C)(C)C)=O)COCCCCCCCCCCCCCCCC
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制

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批次:

化学结构

Butenoyl PAF