BU 226 hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BU 226 hydrochloride是一种选择性的咪唑啉2受体的配体[1].
咪唑啉受体是可乐宁和其他咪唑啉的主要受体.咪唑啉2受体(I2受体)是一种单胺氧化酶的变构结合位点,在神经保护和疼痛调节中起重要作用.
BU 226 hydrochloride是一种选择性的I2受体的配体.BU226对I2受体表现出较高的亲和力,Ki值为1.4 nM,与对I1受体相比,对I2受体表现出380倍的选择性.此外,BU226对α2肾上腺素受体表现出较低的亲和力.在大鼠脑或肾脏膜中,BU226对I1\I2受体和α2肾上腺素受体表现出亲和力,对I1受体的IC50值为534.5 nM,对I2和α2肾上腺素受体的Ki值分别为2.7和6700 nM[1].在猪大脑中,BU226取代2BFI,Ki值为44.7 nM,这表明咪唑啉I2结合位点的存在[2].
在雄性Hooded Lister大鼠中,BU226(1.6-7.0 mg/kg)剂量依赖性地强效取代2- BFI,ED50值为3.2 mg/kg [3].
参考文献：
[1]. Hudson AL, Gough R, Tyacke R, et al. Novel selective compounds for the investigation of imidazoline receptors. Ann N Y Acad Sci, 1999, 881: 81-91.
[2]. Anderson NJ, Lupo PA, Nutt DJ, et al. Characterisation of imidazoline I2 binding sites in pig brain. Eur J Pharmacol, 2005, 519(1-2): 68-74.
[3]. MacInnes N, Handley SL. Characterization of the discriminable stimulus produced by 2-BFI: effects of imidazoline I(2)-site ligands, MAOIs, beta-carbolines, agmatine and ibogaine. Br J Pharmacol, 2002, 135(5): 1227-1234.
| Physical Appearance | Off-white solid |
| Storage | Store at RT |
| M.Wt | 233.7 |
| Cas No. | 1186195-56-1 |
| Formula | C12H11N3·HCl |
| Solubility | Soluble to 100 mM in H2O |
| Chemical Name | 3-(4,5-dihydro-1H-imidazol-2-yl)isoquinoline hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | C12=CC=CC=C1C=NC(C3=NCCN3)=C2.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
